Purpose. We report the effect of isotretinoin on corneal topography, corneal thickness, and biomechanical parameters in patients\nwith acne vulgaris. Method. Fifty-four eyes of 54 patients who received oral isotretinoin for treatment of acne vulgaris were\nevaluated. All patients underwent a corneal topographical evaluation with a Scheimpflug camera combined with Placido-disk\n(Sirius), ultrasonic pachymetry measurements, and corneal biomechanical evaluation with an ocular response analyzer at baseline,\nin the 1st, 3rd, and 6th months of treatment, and 6months after isotretinoin discontinuation. Results.The thinnest corneal thickness\nmeasured with Sirius differed significantly in the 1st, 3rd, and 6th months compared with the baseline measurement; there was\nno significant change in ultrasonic central corneal thickness measurements and biomechanical parameters (corneal hysteresis\nand corneal resistance factor) throughout the study. Average simulated keratometry and surface asymmetry index increased\nsignificantly only in the first month of treatment according to the baseline. All changes disappeared 6 months after the end of\ntreatment. Conclusion. Basal tear secretion and corneal morphologic properties were significantly influenced during the systemic\nisotretinoin treatment and the changes were reversible after discontinuation. No statistical important biomechanical differences\nwere found to be induced by isotretinoin.
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